Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.
How to use Denovo
Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.
Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician.
If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.
Active Ingredients: 15mg L-methylfolate (L-5-MTHF from L-5-methyltetahyrofolate calcium salt)
Inactive Ingredients: microcrystalline cellulose, gelatin, vegetable magnesium stearate, silica, titanium dioxide, FD&C yellow #5k, FD&C yellow #6
Uses: Denovo® is indicated for the distinct metabolic requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and/or red blood cells and have major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant.
Warnings: Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations.) 5-MTHF may be less likely than folic acid to mask B12 deficiency. Folate therapy alone is inadequate for the treatment of B12 deficiency.
Caution is recommended in patients with a history of bipolar illness. Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder.
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